For your reference, I offer Buffalo
https://buffalophotoblog.com/ghost-signs-of-buffaloIn almost every case, the graphic design of the sign is independent of structural member spacing and/or window patterns. The only exception is when a sign element is designed to be read vertically and has to fit between windows.
It's more important for the lettering to be clear and legible (and of course, weathered to death to almost be neither!) rather than it "fit" into the building itself.
You can probably find examples that disagree with that, but in this sampling, the sign is almost always more important than the surface it's on.
Here's a particularly jarring example, screen shot from the above site's gallery:
The lettering has no regard for the structure, or in fact, the colors of the wall!
Lee