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I would think that a ton of hours would need to be logged before there is any discernible difference in performance. You have a small contact region coupled with dis-similar materials in the stainless steel metal axle and the acetyl plastic sideframes. This would apply to all high-quality machined wheelsets, not just ESM.
On some used cars I have bought, I have seen some trucks that have wear impressions of axel points in the truck bearing surfaces. I found those while investigating the poor rolling qualities. At the point where I received them, they usually did not have the wheels that made the impressions - apparently the sellers took the "good wheels" out and put some plastic pizza cutters or other cheap wheels in before the sale to me. So, I have no idea what caused the wear impressions - I just know that something can do that. (I doubt they were your ESM wheels, though, given the dates of things.)