I have just used the standard slicer and since the first print have placed all supports manually.
For the first few prints, using 30% density, I would look at their version of what support might look like (automatic) to get a sense of what they thought it should be and then clear those and start placing manually. When using the automatic slicer, the first thing that became apparent was that they didn't get the supports everywhere that they needed to be and also didn't give any consideration to what the part would look like when completed, therefore no consideration to where the supports were attached. Example, placing a support right in the middle of a bearing surface, or right through a delicate edge, or on the exposed face instead of the directly opposite hidden face. By placing them manually these considerations can be made and size and exact placement can be adjusted to the need. Also you can consider the part shape and where it might be rigid and where it might tend to sag and then place the supports accordingly. One thing I discovered was that often fewer supports were required but also that in key areas, thin corners for example, additional support was needed to prevent sagging or worse.
Then consider the size of the supports. When placed frequently enough it seems that the engagement diameter of the "top" adds no additional benefit past .6 diameter and is what I'll use whenever the surface/ space allows. Down to .5/ .4 is still pretty robust and I've used less but if needed that small I might increase the frequency a little. It's a judgement call. One advantage to keeping the engagement at .6 or less is that none of them seem to be so strong that they damage the surface they are attached to, ripping out a chunk of the part on removal.
Then consider the engagement depth dimension. I leave the default at "0" because I'm generally engaging square on flat faces so additional engagement depth accomplishes nothing. The engagement is already full diameter. When near an edge it prevents the support from extending down the edge of the part it's attached to, effecting that face dimension or finish. Where I might increase that number is engaging a round surface where I think I need the "grip" and it won't deform the surface or be visible on removal.
Then there's the "mid" section. Again, I have used .6 most often but if the support will be very tall and is one of the key supports for stabilizing the whole part, that could be increased. A judgement call. If there are delicate supports that are so close to each other that the mid overlaps, tying in to the adjacent support, then I might reduce the mid to just engage that adjacent support and sharing the stability with it. Both become more stable. This might appear on supports to things like small rivet detail.
These are just some of the things that I've arrived at with my own limited experience.
There are still a lot of judgement calls but hopefully these things will help in the early learning stages... which most of us are not far from.