I've used Digitrax, happily, since 1995 when I bought my first Chief set with the old horrible DT100 throttle. While I would be the first to admit the interface isn't exactly user-friendly, I've gotten used to it. Moreover, it is the system used by our club and club members, so there's lots of troubleshooting help available.
But I will say that one feature of the ESU LokSound decoders is easier to use on NCE. The new Full Throttle features can only be used in an MU consist by using Advanced Consisting (decoder-assisted consisting, in CV19, 21 and 22). NCE automatically uses Advanced Consisting when setting up a consist; Digitrax does not - instead, all the consist information is kept in the command station (their Universal consisting). I've never before needed or even been interested in using Advanced Consisting; now I am, and while that is doable with Digitrax by manually prorgramming CV19, it is much more difficult than with NCE, which does it automatically from the throttle when you set up a consist.
So there ARE some potential operational differences that might impact end users in certain very specific situations. In general, I still think Loconet beats the competition, and the new DT402 throttles are much easier to use. But I sure wish Digitrax would copy NCE's method of making and breaking consists!
John C.